Reportedly, an international team of researchers from the IBSAL (Institute of Biomedical Research of Salamanca), Gero Discovery, and Nanosyn, Inc. has discovered a promising drug that might prevent neuronal fatality through glucose metabolism variation in stressed neurons. The positive outcomes seen in mice are promising for prospect use in humans. The novel drug can have applications in neurological conditions such as amyotrophic lateral sclerosis, Huntington’s disease, Alzheimer’s disease, TBI (traumatic brain injury), and ischemic stroke. The findings of the research were published in the journal Scientific Reports.
Neurological disorders and brain injuries are key reasons of death across the globe. As per WHO (World Health Organization), stroke is the second-most normal cause of death and over a third of people who sustained a stroke have a serious disability. And since the population ages, millions of more people are prone to develop Parkinson’s or Alzheimer’s diseases in the near future. Nevertheless, there are no effective treatments for the foremost neurodegenerative diseases. It is therefore seriously important to know the biology of these diseases and to find out new drugs capable of improving survival, quality of life, and, in the best-case setting, curing the disease entirely.
On a similar note, a study showed that particular cells produce a substance in the brain that shields neurons. The researchers at the USC (University of South California) have found a key in the brain’s vascular system that safeguards the neurons required to keep diseases such as dementia bay. The finding aims at particular cells known as pericytes and discloses that they play a role—which was previously unknown—in the health of the brain. The pericytes produce a substance that keeps neurons lively, even in the incidence of leaky blood vessels that fetid brain matter and outcome in cognitive decline.